After 23 horrifying days of gorging on human flesh, an ancient creature known as the Creeper embarks on a final voracious feeding frenzy, terrorizing a group of varsity basketball players, cheerleaders and coaches stranded on a remote highway when their bus breaks down. The terrified group is forced to come together and do battle against the winged creature hell-bent on completing its grizzly ritual.
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While on her bachelorette party getaway, Casey, the bride to be, gets a seemingly harmless bite from an unknown insect. After returning home with cold feet, Casey tries to call off her wedding but before she’s able to, she starts exhibiting insect like traits. Between her physical transformation and her wedding anxiety, Casey succumbs to her new instincts and begins creating a hive that not only houses her translucent eggs, but feeds on the flesh of others. As her transformation becomes complete, Casey discovers that everything can change with a single bite.
Barney Ross leads a band of highly skilled mercenaries including knife enthusiast Lee Christmas, a martial arts expert, heavy weapons specialist, demolitionist, and a loose-cannon sniper. When the group is commissioned by the mysterious Mr. Church to assassinate the dictator of a small South American island, Barney and Lee visit the remote locale to scout out their opposition and discover the true nature of the conflict engulfing the city.