Three college students, Phil, Ed, and Henry take a road trip into Mexico for a week of drinking and carefree fun only to have Phil find himself a captive of a group of satanic Mexican drug smugglers who kill tourists and whom are looking for a group of new ones to prepare for a sacrifice.
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Nicky, a veteran con artist, takes a novice named Jess under his wing. While Nicky teaches Jess the tricks of the trade, the pair become romantically involved; but, when Jess gets uncomfortably close, Nicky ends their relationship. Three years later, Nicky is in Buenos Aires working a very dangerous scheme when Jess — now an accomplished femme fatale — unexpectedly shows up. Her appearance throws Nicky for a loop at a time when he cannot afford to be off his game.
Deputy Sheriff Lou Ford is a pillar of the community in his small west Texas town, patient and apparently thoughtful. Some people think he is a little slow and maybe boring, but that is the worst they say about him. But then nobody knows about what Lou calls his “sickness”: He is a brilliant, but disturbed sociopathic sadist.
Deep in the Northern California woods, in the heart of the notorious Emerald Triangle, lies a remote cabin. The residents struggle to fight off the repeated attacks and abductions by mysterious creatures that have plagued them for years. When a local pot farmer is caught up with a wayward group of campers the situation quickly escalates into total carnage.
When their city is rocked by a series of brutal occult murders, veteran detective John Locke and his young partner Terri Keyes are forced to put aside their differences and follow the trail of evidence to a formerly abandoned asylum, where the new owner Dr Unnseine is conducting his own brand of Nazi-inspired “medical research” on the unwilling inmates. One such inmate, the sexy but deadly Annie Dyer, may hold the key to the murders – and to the doorway to Hell itself – if only Locke and Keyes can stay alive long enough to discover what it is.
A boy named George Jung grows up in a struggling family in the 1950’s. His mother nags at her husband as he is trying to make a living for the family. It is finally revealed that George’s father cannot make a living and the family goes bankrupt. George does not want the same thing to happen to him, and his friend Tuna, in the 1960’s, suggests that he deal marijuana. He is a big hit in California in the 1960’s, yet he goes to jail, where he finds out about the wonders of cocaine. As a result, when released, he gets rich by bringing cocaine to America. However, he soon pays the price.